Mikhail V Blagosklonny Selected Research

Sirolimus (Rapamycin)

12/2020	From causes of aging to death from COVID-19.
10/2019	Rapamycin for longevity: opinion article.
1/2019	Fasting and rapamycin: diabetes versus benevolent glucose intolerance.
1/2019	The mystery of the ketogenic diet: benevolent pseudo-diabetes.
12/2016	Gerosuppression by pan-mTOR inhibitors.
1/2015	Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats.
8/2014	Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet.
6/2014	Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program.
5/2014	Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin.
1/2014	Comparison of rapamycin schedules in mice on high-fat diet.

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Mikhail V Blagosklonny Research Topics

Disease

54	Neoplasms (Cancer) 08/2021 - 01/2002
11	Hypoxia (Hypoxemia) 06/2014 - 01/2002
7	Carcinogenesis 12/2017 - 03/2002
7	Hypertrophy 12/2016 - 12/2006
6	Starvation 01/2019 - 11/2008
6	Obesity 01/2019 - 09/2006
4	Insulin Resistance 01/2019 - 03/2009
4	Atherosclerosis 05/2017 - 09/2006
4	Breast Neoplasms (Breast Cancer) 12/2014 - 03/2003
4	Leukemia 05/2005 - 03/2003
3	Weight Gain 01/2014 - 05/2010
3	Macular Degeneration (Age-Related Maculopathy) 08/2012 - 03/2009
2	Oncogene Addiction 08/2021 - 05/2004
2	Hypertension (High Blood Pressure) 12/2020 - 09/2006
2	Stroke (Strokes) 10/2019 - 09/2006
2	Glucose Intolerance 01/2019 - 12/2011
2	Type 2 Diabetes Mellitus (MODY) 01/2019 - 10/2012
2	Diabetes Complications 01/2019 - 12/2011
2	Body Weight (Weight, Body) 01/2014 - 12/2012
2	Fibrosarcoma 06/2009 - 06/2007
2	Osteoporosis 03/2009 - 09/2006
2	Carcinoma (Carcinomatosis) 06/2007 - 12/2004
2	Tetraploidy 07/2006 - 08/2004
1	COVID-19 12/2020
1	Infarction (Infarctions) 10/2019
1	Blindness (Hysterical Blindness) 10/2019
1	Epilepsy (Aura) 01/2019
1	Alzheimer Disease (Alzheimer's Disease) 01/2019
1	Hyperglycemia 01/2019
1	Hyperplasia 01/2015
1	Inflammation (Inflammations) 01/2015
1	Acidosis 01/2014
1	Demyelinating Diseases (Demyelinating Disease) 06/2013
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2012
1	Progeria (Hutchinson Gilford Syndrome) 07/2011
1	Diabetic Retinopathy (Retinopathy, Diabetic) 05/2011
1	Shock 02/2011
1	Melanoma (Melanoma, Malignant) 06/2010

Drug/Important Bio-Agent (IBA)

34	Sirolimus (Rapamycin)FDA Link 12/2020 - 09/2006
11	Pharmaceutical PreparationsIBA 07/2012 - 01/2002
7	MTOR InhibitorsIBA 12/2017 - 07/2012
7	Proteins (Proteins, Gene)FDA Link 12/2012 - 03/2002
5	Doxorubicin (Adriamycin)FDA LinkGeneric 06/2007 - 09/2002
4	nutlin 3IBA 08/2012 - 06/2010
4	Cytostatic AgentsIBA 11/2011 - 03/2002
4	DNA (Deoxyribonucleic Acid)IBA 02/2011 - 09/2002
4	Drug CombinationsIBA 07/2007 - 04/2004
4	MitogensIBA 05/2005 - 01/2002
3	Everolimus FDA Link 10/2019 - 12/2013
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2014 - 11/2002
3	Cytotoxins (Cytolysins)IBA 02/2011 - 03/2002
3	Phosphotransferases (Kinase)IBA 02/2005 - 11/2002
2	Oncogene Proteins (Oncogene Protein)IBA 12/2013 - 04/2004
2	Insulin (Novolin)FDA Link 12/2012 - 12/2011
2	Oxygen (Dioxygen)IBA 11/2012 - 07/2005
2	Etoposide (VP 16)FDA LinkGeneric 08/2012 - 12/2010
2	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 05/2011 - 07/2005
2	Metformin (Glucophage)FDA LinkGeneric 03/2011 - 09/2008
2	Paclitaxel (Taxol)FDA LinkGeneric 07/2006 - 09/2002
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2005 - 03/2002
2	Histone Deacetylases (Histone Deacetylase)IBA 08/2005 - 05/2004
2	romidepsin (FK228)FDA Link 08/2005 - 03/2002
2	Histone Deacetylase InhibitorsIBA 08/2005 - 03/2002
2	Proteasome Endopeptidase Complex (Proteasome)IBA 07/2005 - 05/2004
2	Gefitinib (Iressa)FDA Link 02/2005 - 05/2004
1	SenotherapeuticsIBA 08/2021
1	Biological ProductsIBA 12/2020
1	Calcineurin InhibitorsIBA 01/2019
1	oil red OIBA 12/2016
1	Sulpiride (neogama)IBA 01/2015
1	Testosterone (Sustanon)FDA Link 01/2015
1	Finasteride (Propecia)FDA LinkGeneric 01/2015
1	Drinking WaterIBA 01/2014
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2014
1	OligomycinsIBA 01/2014
1	LeptinIBA 01/2014
1	ridaforolimusIBA 12/2013
1	Immunosuppressive Agents (Immunosuppressants)IBA 12/2013
1	MicellesIBA 10/2012
1	TOR Serine-Threonine KinasesIBA 10/2012
1	Retinaldehyde (Retinal)IBA 08/2012
1	Progesterone FDA LinkGeneric 07/2012
1	VimentinIBA 07/2012
1	Estrogens (Estrogen)FDA Link 07/2012
1	CaveolinsIBA 07/2012
1	Caveolin 1IBA 07/2012
1	KetonesIBA 12/2011
1	Lipoproteins (Lipoprotein)IBA 12/2011
1	ResveratrolIBA 11/2011
1	Glucose (Dextrose)FDA LinkGeneric 03/2011
1	CytokinesIBA 02/2011
1	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA 06/2009
1	U 0126 (UO 126)IBA 06/2009
1	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 06/2009

Therapy/Procedure

20	Therapeutics 08/2021 - 03/2002
11	Drug Therapy (Chemotherapy) 12/2012 - 11/2002
1	Ketogenic Diet 01/2019
1	Caloric Restriction 01/2019
1	Intraperitoneal Injections 01/2014
1	Chemoprevention 07/2012